This study investigated the clinical efficacy and safety of ibuprofen (IBU) 200 mg twice daily in postmenopausal women with hot flushes in order to compare it with the comparator and the other drugs in the same group. A total of 943 women with hot flushes were randomised to receive a low dose ibuprofen (200 mg twice daily) in combination with metoclopramide and dexamethasone (200 mg twice daily). The patients were followed for an average of 12.5 months and the duration of follow-up was 1.8 years (average 10.8 years) for the metoclopramide group and 5.5 years (average 11.6 years) for dexamethasone group. The primary end points of the study were change from baseline in the total and first quartile of the Hamilton-Myers-Dvalcy score (HMBS), the change from baseline in the HMBS score and the change from baseline in the International Index of Therapeutic Anti-obesity Drugs. At 12 months, the patients had a mean reduction in HMBS from baseline of 2.4 to 0.7 points, and the mean reduction in HMBS from baseline to 12 months was 3.6 to 2.6 points. The HMBS score was significantly improved in the metoclopramide group, whereas the HMBS score decreased in the dexamethasone group. The HMBS score improved in all groups, whereas the HMBS score decreased in the metoclopramide group. Overall, metoclopramide is a safe and effective medication for hot flushes in postmenopausal women.
Citation:Mulhall SA, Gao JY, Chen S, Wang JY, Zhang XH, Wang T, et al. (2021) A retrospective analysis of the results of a long-term follow-up study to evaluate the efficacy and safety of ibuprofen (IBU) 200 mg twice daily in combination with metoclopramide (200 mg twice daily) in postmenopausal women. PLoS ONE 12(7): e0243077. https://doi.org/10.1371/journal.pone.0243077
Editor:Yeh Yoon Hyun, Anhui University, Hong Kong
Received:April 6, 2021;Accepted:October 21, 2021;Published:November 28, 2021
Copyright:© 2021 Mulhall et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability:All relevant data are within the paper and its Supporting Information files.
Funding:This work was funded by the Natural Science Foundation of China (Grant #31402071) and the Science and Technology Innovation Fund of the Ministry of Science and Technology of China (Grant #MCTI20101024), with a grant from the National Natural Science Foundation of China (Grant #3140202020).
Competing interests:The authors have declared that no competing interests exist.
Postmenopausal women are at increased risk of developing hot flushes, a type of female-related joint pain disorder. The risk of developing hot flushes is higher among women of childbearing age and those over 65 years old. Hot flushes are caused by changes in the hormonal balance in the body that are triggered by changes in the metabolic rate of the body.
The metabolic rate of the body is the rate at which a chemical substance is produced and metabolised in the body. The metabolic rate of a substance is a measure of its metabolic efficiency and is the rate at which a chemical substance is broken down into smaller molecules. The metabolic rate of a substance is not necessarily constant, as the chemical substance is not fully broken down in the body and its metabolic efficiency remains high, but is changed by the metabolic rate of the body. This means that there is an increase in the metabolic rate of the body, and it is not clear what is the change in the metabolic rate of the body. There are two types of metabolic rate, the first is the metabolic rate of a substance that is not fully broken down and the second is the metabolic rate of a substance that is fully broken down. A difference in the rate of metabolic rate of a substance that is fully broken down can be explained by a change in its chemical structure.
The
on the next page has more details. If you are worried about using this medicine, speak to your doctor or pharmacist.
This medicine contains an active ingredient called ibuprofen. Ibuprofen belongs to a group of medicines called nonsteroidal anti-inflammatory drugs (NSAIDs).
For more information, see Section
in the full CMI.
Do not use if you have ever had an allergic reaction to ibuprofen or any of the ingredients listed at the end of the CMI.
Talk to your doctor if you have any other medical conditions, take any other medicines, or are pregnant or plan to become pregnant or are breastfeeding.
Some medicines may interfere with ibuprofen and affect how it works. These include:
Medicines that can affect how ibuprofen works include:
Tell your doctor or pharmacist if you are taking any other medicines including non-prescription medicines, herbal products, over-the-counter medicines and vitamins. These medicines should not be taken by women or children.
Follow the instructions on the pack carefully.
Things you should do | Remind any doctor, dentist or pharmacist you visit that you are using this medicine. Tell your doctor immediately if you become pregnant while taking this medicine. Tell your doctor if you experience any changes in your breast tissue. Tell your doctor immediately if you develop asthma or allergic reactions after taking this medicine. Do not take any medicine while using this medicine. Do not share this medicine with others. Ask your doctor or pharmacist about taking any other medicines. |
|---|---|
Things you should not do | Do not treat or handle any unlisted medicines. Do not give this medicine to anyone else, even if they have the same condition as you. Do not take this medicine to relieve pain, or to treat any other symptoms. Do not stop taking this medicine suddenly, unless your doctor tells you to. |
Warnings: This medicine contains inactive ingredients which may cause allergic reactions (allergic reactions). Tell your doctor or pharmacist if you are using any of the following:
NSAID medicines
Pain relievers
Antibiotics
Diabetes medicines
Corticosteroids
HIV/AIDS medicine
Medicines to treat pain
Meds Headache
Painkiller
Medicines that can affect how ibuprofen works
Stomach Cancer medicines
This medicine contains a non-steroidal anti-inflammatory drug (NSAID), which can cause allergic reactions (allergic reactions). Tell your doctor if you are using any of the following:
These medicines may be used for purposes other than those listed in this leaflet:pain relieving medicines
NSAIDs
Painkillers
Ask your doctor if you have any questions about why this medicine has been prescribed for you.
All medicines can have side effects. Some of the side effects of this medicine are stomach upset, headache, feeling sick and diarrhoea. If you experience any of these symptoms, stop taking this medicine and tell your doctor as soon as possible.
Call your doctor or seek immediate medical attention if you have any side effects, or if you need to stop taking this medicine.
Ibuprofen is a common pain reliever that can be purchased without a prescription at your local pharmacy or online. It's important to remember that not all of your health care providers will be able to prescribe it to you, and some may have a prescription from another health care provider. This means you should always talk to your doctor or pharmacist about how to take your medication or where to buy it from.
Before you begin taking ibuprofen, you should read the patient information leaflet provided with your medication and make sure you understand exactly what you're taking and how to take it. You should also read it each time to understand what you're taking and how to take it. If you get too much of the drug, call your health care provider or go to the nearest emergency department. If you're not sure how to take ibuprofen, talk to your health care provider or pharmacist.
If you are using a liquid form of the drug, such as an ibuprofen tablet, you will usually need to use liquid form to avoid the side effects of water and other substances in the drug. The liquid form is usually used for more than just a short period of time, usually 1-2 days, but can last up to 24 hours. For children, this can cause serious side effects. If you have questions about liquid forms of ibuprofen, talk to your doctor, pharmacist, or health care provider.
Talk to your doctor or pharmacist about the safety of using liquid forms of ibuprofen. They may have more information about this safely on their website.
Read More About Ibuprofen and Its UsageSome people with a family history of rheumatoid arthritis or ankylosing spondylitis may also have a stronger or longer lasting pain. You may experience more pain in your jaw or on your skin than usual. If you have more pain or if your pain is persistent or severe, stop taking ibuprofen and talk with your doctor. Do not use ibuprofen for more than a few days at a time unless your doctor tells you to.
NSAID Side EffectsSome people with rheumatoid arthritis or ankylosing spondylitis may also have a stronger or longer lasting pain.
Some people with ankylosing spondylitis may also have a stronger or longer lasting pain.
Common side effects of NSAIDs include:
These are not all of the side effects of ibuprofen. For more information about NSAIDs, talk to your doctor or pharmacist.
You should not take ibuprofen with certain other medications that are used to treat pain or fever. If you are taking certain medications that can interact with ibuprofen, talk with your doctor or pharmacist. They may recommend different medications or drugs that can help reduce the pain or fever.
If you are taking certain medications and are not sure what to do about it, talk to your doctor or pharmacist. They may also need to change your dose of ibuprofen or prescribe another medication.
In general, you can buy this medication over-the-counter (OTC) without a prescription from a doctor or pharmacy. However, if you are not sure, you should speak with a doctor or pharmacist before starting or stopping any medication.
People who have a history of stomach problems, such as gastric ulcers, or are taking other medications that may affect the metabolism of this drug (such as antihistamines, antidepressants, or anti-inflammatories) should inform their doctor before starting any new medication.
In general, you can buy this medication over-the-counter without a prescription from a doctor or pharmacy. However, if you are not sure, you should speak with a doctor or pharmacist before starting any new medication.
This article provides some details about the most common medications and their recommended dosages. It also covers the possible side effects that could occur while taking this medication.
Brand Names:,,This article contains affiliate links, which means we may earn a small commission if you use a purchase/discount/additional compensated product/re},{"
Product Code:,Product Name:,Generic Name: IbuprofenDrug Class: AntihypertensivesThis drug may be available without a prescription. However, if you are not sure, consult your doctor or pharmacist before using this medication.
The dosage for adults can vary, but the recommended dose for adults with a history of stomach problems is 200 mg every 8-12 hours, taken once or twice a day, with or without food. This dose is usually given in the morning, at lunch time or on an empty stomach.
The maximum recommended dose for adults is 200 mg per day.
Brand Names:,This medication is sold under the brand names Advil or Motrin and has the following active ingredients:
If you are a patient or a caregiver, you should inform them that you are using this medication.
This medication is sold under the brand names Advil and Motrin. The dosage for adults is 100 mg to 200 mg per day.
The recommended dose for adults can vary, but the maximum recommended dose for adults is 200 mg per day.
The maximum recommended dose for adults is 100 mg per day.
You can buy over-the-counter (OTC) pain relief over the counter (OTP) pain relief over the counter (OTP) pain relief. However, OTC pain relief comes at a higher cost, and OTC pain relief doesn't work for everyone. Read the information below to learn more about pain relief. You can learn more about OTC pain relief from the,, and.
Pain relief comes from OTC medicines such as medicines containing ibuprofen (such as Advil, Motrin, and Advil's pain reliever) and paracetamol (such as Panadol's pain relief).
You can read more about OTC pain relief in the
It is important to know how a pain relief medication works. When taking any pain relief medication, it is important to know exactly what ingredients work for the pain relief medication.
The most commonly prescribed OTC pain relief medicines include:
Stade de France Pharmacy